Articles

  1. Vitale G, Filaferro M, Micioni Di Bonaventura MV, Ruggieri V, Cifani C, Guerrini R, Simonato M, Zucchini S. Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioral alterations associated with chronic mild stress. J Psychopharmacol., in press.
  2. Roncon P, Zucchini S, Ferracin M, Marucci G, Giulioni M, Michelucci R, Rubboli G, Simonato M. Is autopsy tissue a valid control for epilepsy surgery tissue in microRNA studies? Epilepsia Open, in press.
  3. Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A. Common data elements and data management: Remedy to cure underpowered preclinical studies. Epilepsy Res. 129, 87-90, 2016. → PubMed LINK
  4. Crespel A, Ferlazzo E, Franceschetti S, Genton P, Gouider R, Kälviäinen R, Korja M, Lehtinen MK, Mervaala E, Simonato M, Vaarmann A. Unverricht-Lundborg disease. Epileptic Disord. 18(S2), 28-37, 2016. → PubMed LINK
  5. Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya S, Kokaia M, Beck H. Advances in the development of biomarkers in Epilepsy. Lancet Neurol. 15, 843-56, 2016.→ PubMed LINK
  6. Falcicchia C, Trempat P, Binaschi A, Perrier-Biollay C, Roncon P, Soukupova M, Berthommé H, Simonato M. Silencing status epilepticus-induced BDNF expression with Herpes Simplex Virus type-1 based amplicon vectors. PLoS ONE 11, e0150995, 2016. → PubMed LINK
  7. Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan A, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. J. Neurosci. Meth. 260, 2–25, 2016. → PubMed LINK
  8. Roncon P, Soukupovà M, Binaschi A, Falcicchia C, Zucchini S, Ferracin M, Langley SR, Petretto E, Johnson MR, Marucci G, Michelucci R, Rubboli G, Simonato M. MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy – comparison with human epileptic samples. Sci. Rep. 5, 14143, 2015.   → PubMed LINK
  9. Soukupova M, Binaschi A, Falcicchia C, Palma E, Roncon P, Zucchini S, Simonato M. Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats. Neuroscience. 301, 246-53, 2015.→ PubMed LINK
  10. Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Meza Santoscoy PL, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo F, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O’Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey A, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto E. Systems-genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nature Comm 6:6031, 2015. → PubMed LINK
  11. Miyagawa Y, Marino P, Verlengia G, Uchida H, Goins WF, Yokota S, Geller DA, Yoshida O, Mester J, Cohen JB, Glorioso JC. Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity. Proc Natl Acad Sci U S A 112:E1632-41, 2015. → PubMed LINK
  12. Simonato M, Brooks-Kayal AR, Engel J Jr, Galanopoulou AS, Jensen FE, Moshé SL, O’Brien TJ, Pitkanen A, Wilcox KS, French JA. The challenge and promise of anti-epileptic therapy development in animal models. Lancet Neurol 13, 949-60, 2014  → PubMed LINK
  13. Zucchini S, Marucci G, Paradiso B, MD, Lanza G, Roncon P, Cifelli P, Ferracin M, Giulioni M, Michelucci R, Rubboli G, Simonato M. Identification of miRNAs differentially expressed in human epilepsy with or without granule cell pathology. PLOS ONE 9, e105521, 2014. → PubMed LINK
  14. Rossignol E, Kobow K, Simonato M, Loeb JA, Grisar T, Gilby KL, Vinet J, Kadam SD, Becker AJ. WONOEP appraisal: New genetic approaches to study epilepsy. Epilepsia 55, 1170-86, 2014. → PubMed LINK
  15. Soukupová M, Binaschi A, Falcicchia C, Zucchini S, Roncon P, Palma E, Magri E, Grandi E, Simonato M. Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy. Exp Neurol 257, 39-49, 2014. → PubMed LINK
  16. Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. Finding a better drug for epilepsy: Antiepileptogenesis targets. Epilepsia 53, 1868-1876, 2012. → PubMed LINK
  17. Simonato M, French JA, Galanopoulou AS, O’Brien TJ. Issues for new antiepilepsy drug development. Curr Opin Neurol 26, 195-200, 2013. → PubMed LINK
  18. Zucchini S, Pittaluga A, Brocca-Cofano E, Summa M, Fabris M, De Michele R, Bonaccorsi A, Busatto G, Barbanti-Brodano G, Altavilla G, Verlengia G, Cifelli P, Corallini A, Caputo A, Simonato M. Increased excitability in tat-transgenic mice: Role of tat in HIV-related neurological disorders. Neurobiol Dis 55, 110-119, 2013. → PubMed LINK
  19. Simonato M, Bennett J, Boulis NM, Castro MG, Fink DJ, Goins WF, Gray SJ, Lowenstein PR, Vandenberghe LH, Wilson TJ, Wolfe JH, Glorioso JC. Progress in gene therapy for neurological disorders. Nat Rev Neurol 9, 277-291, 2013. → PubMed LINK
  20. Rodi D, Buzzi A, Barbieri M, Zucchini S, Verlengia G, Binaschi A, Regoli D, Boschi A, Ongali B, Couture R, Simonato M. Bradykinin B2 receptors increase hippocampal excitability and susceptibility to seizures in mice. Neuroscience 248, 392-402, 2013. → PubMed LINK
  21. Cifelli P, Palma E, Roseti C, Verlengia G, Simonato M. Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy. Front Cell Neurosci 7, 108, 2013. → PubMed LINK
  22. Galanopoulou AS, Simonato M, French JA, O’Brien TJ. Joint AES/ILAE translational workshop to optimize preclinical epilepsy research. Epilepsia 54 (S4), 1-2, 2013. → PubMed LINK
  23. O’Brien TJ, Ben-Menachem E, Bertram EH 3rd, Collins SD, Kokaia M, Lerche H, Klitgaard H, Staley KJ, Vaudano E, Walker MC, Simonato M. Proposal for a “phase II” multicenter trial model for preclinical new antiepilepsy therapy development. Epilepsia 54 (S4), 70-74, 2013. → PubMed LINK
  24. Paradiso B, Zucchini S, Simonato M. Implication of fibroblast growth factors in epileptogenesis-associated circuit rearrangements. Front Cell Neurosci 7, 152, 2013. → PubMed LINK
  25. Simonato M. Gene therapy for epilepsy. Epilepsy Behav, in press, 2013. → PubMed LINK
  26. Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel JJr, Loscher W, Noebels JL, Pitkanen A, Stables J, White SH, O’Brien TJ, Simonato M. Identification of new treatments for epilepsy: issues in preclinical methodology. Epilepsia 53, 571–582, 2012. → PubMed LINK
  27. Buzzi A, Chikhladze M, Falcicchia C, Paradiso B, Lanza G, Soukupova M, Marti M, Morari M, Franceschetti S, Simonato M. Loss of cortical GABA terminals in Unverricht–Lundborg disease. Neurobiol Dis 47, 216–224, 2012. → PubMed LINK
  28. Su T, Scardigli R, Fasulo L, Paradiso B, Barbieri M, Binaschi A, Bovolenta R, Zucchini S, Cossu G, Cattaneo A, Simonato M. By-stander effect on brain tissue of mesoangioblasts producing neurotrophins. Cell Transplantation 21, 1613-27, 2012. → PubMed LINK
  29. Simonato M, Loescher W, Cole AJ, Dudek FE, Engel JJr., Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velisek L, Klitgaard H. Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial design. Epilepsia, 53, 1860-1867, 2012. → PubMed LINK
  30. Marti M, Rodi D, Li Q, Guerrini R, Fasano S, Morella I, Tozzi A, Brambilla R, Calabresi P, Simonato M, Bezard E, Morari M. Nociceptin/Orphanin FQ Receptor Agonists Attenuate L-DOPA-Induced Dyskinesias. J Neurosci. 32, 16106-16119, 2012. → PubMed LINK
  31. Paradiso B., Zucchini S., Su T., Bovolenta R., Berto E., Marconi P., Marzola A., Navarro Mora G., Fabene P.F., SIMONATO M. Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to four weeks after pilocarpine-induced status epilepticus. Epilepsia 52, 572-578, 2011. → PubMed LINK
  32. Su T, Paradiso B, Long YS, Liao WP, Simonato M. Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection. Brain Res 1385, 68-76, 2011. → PubMed LINK
  33. Mazzuferi M, Bovolenta R, Bocchi M, Braun T, Bauer J, Jung E, Iafelice B, Guerrieri R, Destro F, Borgatti M, Bianchi N, Simonato M, Gambari R. The biocompatibility of materials used in printed circuit board technologies with respect to primary neuronal and K562 cells. Biomaterials 31, 1045-1054, 2010. → PubMed LINK
  34. Mazzuferi M, Palma E, Martinello K, Maiolino F, Roseti C, Fucile S, Fabene PF, Schio F, Pellitteri M, Sperk G, Miledi R, Eusebi F, Simonato M. Enhancement of GABAA-current run-down in the hippocampus occurs at the time of the first spontaneous seizure in a model of temporal lobe epilepsy. Proc Natl Acad Sci USA 107, 3180-3185, 2010. → PubMed LINK
  35. Simonato M., Zucchini S. Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis? Epilepsia 51(S3), 48–51, 2010.
  36. Marti M., Sarubbo S., Latini F., Cavallo M., Eleopra R., Biguzzi S., Lettieri C., Conti C., Simonato M., Zucchini S., Quatrale R., Sensi M., Candeletti S., Romualdi P., Morari M. Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson’s disease. Mov Disorders 25, 1723-1732, 2010.
  37. Bovolenta R., Zucchini S., Paradiso B., Rodi D., Merigo F., Navarro Mora G., Osculati F., Berto E., Marconi P., Marzola A., Fabene P.F., Simonato M. Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. J Neuroinflammation, 7:81, 2010.
  38. Paradiso B., Marconi P., Zucchini S., Berto E., Binaschi A., Bozac A., Buzzi A., Mazzuferi M, Magri E., Navarro Mora G., Rodi D., Su T., Volpi I., Zanetti L., Marzola A., Manservigi R., Fabene P.F., Simonato M. Localized delivery of FGF-2 and BDNF reduces spontaneous seizures in an epilepsy model. Proc Natl Acad Sci USA, 106, 7191-7196, 2009.
  39. Pignatelli A, Ackman JB, Vigetti D, Beltrami AP, Zucchini S, Belluzzi O. A potential reservoir of immature dopaminergic replacement neurons in the adult mammalian olfactory bulb. Pflugers Arch 457:899-915, 2009.
  40. Chiaruttini C., Sonego M., Baj G., Simonato M., Tongiorgi E. BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol. Cell. Neurosci. 37, 11-19, 2008.
  41. Rodi D., Zucchini S., Simonato M., Cifani C., Massi M., Polidori C. Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis. Psychopharmacology 196, 523-531, 2008.
  42. Bozzi Y., Vezzani A., Simonato M., de Curtis M., Avanzini G., Caleo M. Fourth Conference on Epileptogenesis. Epilepsia 49, 929-934, 2008.
  43. Roseti C., Martinello K., Fucile S., Piccari V., Mascia A., Di Gennaro G., Quarato P.P., Manfredi M., Esposito V., Cantore G., Arcella A., Simonato M., Fredholm B.B., Limatola C., Miledi R., Eusebi F. Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors. Proc Natl Acad Sci USA 105, 15118-23, 2008.
  44. Zucchini S., Buzzi A., Barbieri M., Rodi D., Paradiso B., Binaschi A., Coffin J.D., Marzola A., Cifelli P., Belluzzi O., Simonato M. FGF-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss. J. Neurosci. 28, 13112-13124, 2008.
  45. Franceschetti S., Sancini G., Buzzi A., Zucchini S., Paradiso B., Magnaghi G., Frassoni C., Chikhladze M., Avanzini G., Simonato M. A pathogenetic hypothesis of Unverricht-Lundborg disease onset and progression. Neurobiol Dis. 25, 675-685, 2007.
  46. Palma E., Roseti C., Maiolino F., Fucile S., Martinello K., Mazzuferi M., Aronica E., Manfredi M., Esposito V., Cantore G., Miledi R., Simonato M., Eusebi F. GABAA-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABAA“phasic” receptors. Proc. Natl. Acad. Sci. USA 104, 20944-20948, 2007.
  47. de Curtis M., Simonato M., Vezzani A., Avanzini G. Third Conference on Epileptogenesis. Epilepsia 47, 1243-1246, 2006.
  48. Simonato M., Tongiorgi E., Kokaia M. Angels and demons: neurotrophic factors and epilepsy. Trends Pharmacol. Sci. 27, 631-638, 2006.
  49. Tongiorgi E., Domenici L., Simonato M. What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development. Mol. Neurobiol. 33, 17-32, 2006.
  50. Ghidini E., Delcanale M., De Fanti R., Rizzi A., Mazzuferi M., Rodi D., Simonato M., Lipreri M., Bassani F., Battipaglia L., Bergamaschi M., Villetti G. Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-amino-acetamide derivatives. Bioorg. Med. Chem., 14, 3263-3274, 2006.
  51. Marconi P., Zucchini S., Berto E., Bozac A., Paradiso B., Bregola G., Grassi C., Volpi I., Argnani R. Marzola A., Manservigi R., Simonato M. Effects of defective herpes simplex vectors expressing neurotrophic factors on the proliferation and differentiation of nervous cells in vivo. Gene Therapy 12, 559-569, 2005.
  52. Rodi D., Couture R., Ongali B., Simonato M. Targeting kinin receptors for the treatment of neurological diseases. Curr. Pharm. Design 11, 1313-1326, 2005.
  53. Zucchini S., Barbieri M., Simonato M. Alterations in seizure susceptibility and in seizure-induced plasticity following pharmacological and genetic manipulation of the Fibroblast Growth Factor-2 system. Epilepsia 46 (S5), 52–58, 2005.
  54. Mazzuferi M., Binaschi A., Rodi D., Mantovani S., Simonato M. Induction of B1 bradykinin receptors in the kindled hippocampus increases extracellular glutamate levels: a microdialysis study. Neuroscience 135, 979-986, 2005.
  55. Marti M., Mela F., Fantin M., Zucchini S., Brown J., Witta J., Di Benedetto M., Buzas B., Reinscheid R.K., Salvatori S., Guerrini R., Romualdi P., Candelotti S., Simonato M., Cox B.M., Morari M. Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson’s disease. J. Neurosci. 25, 9591-9601, 2005.
  56. Martino S, Marconi P, Tancini B, Dolcetta D, De Angelis MG, Montanucci P, Bregola G, Sandhoff K, Bordignon C, Emiliani C, Manservigi R, Orlacchio A. A direct gene transfer strategy via brain internal capsule reverses the biochemical defect in Tay-Sachs disease. Hum Mol Genet. 14(15):2113-23, 2005.
  57. Dumont Y., Gaudreau P., Mazzuferi M., Langlois D., Chabot J.-G., Fournier A., Simonato M., Quirion R. BODIPY®-conjugated Neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. Br. J. Pharmacol. 146, 1069-1081, 2005.
  58. Gallerani M., Simonato M., Manfredini M., Volpato S., Vigna G., Fellin R. Risk of hospitalization for upper gastrointestinal tract bleeding: data from the GIFA study (Gruppo Italiano di Farmacovigilanza nell’Anziano). J. Clin. Epidemiol. 57, 103-110, 2004.
  59. Tongiorgi E., Armellin M., Giulianini P.G., Bregola G., Zucchini S., Paradiso B., Steward O., Cattaneo A., Simonato M. Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J. Neurosci. 24, 6842-6852, 2004.
  60. Aparicio L.C., Candeletti S. , Binaschi A., Mazzuferi M., Mantovani S., Di Benedetto M., Landuzzi D., Lopetuso G., Romualdi P., Simonato M. Kainate seizures increase Nociceptin/Orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study. J. Neurochem. 91, 30-37, 2004.
  61. Rodi D., Polidori C., Bregola G., Zucchini S., Simonato M., Massi M.: Pro-nociceptin/orphanin FQ and NOP receptor mRNA levels in the forebrain of food deprived rats. Brain Res 957, 354-361, 2002.
  62. Binaschi A., Zucchini S., Bregola G., Rodi D., Mazzuferi M., Reinscheid R.K., Simonato M. Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice. Neuroreport 14, 825-827, 2003.
  63. Ongali B., Campos M.M., Bregola G., Rodi D., Regoli D., Thibault G., Simonato M., Couture R. Autoradiographic analysis of rat brain kinin B1 and B2 receptors: Normal distribution and alterations induced by epilepsy. J. Comp. Neurol. 461, 506-519, 2003.
  64. Rodi D., Mazzuferi M., Bregola G., Dumont Y., Fournier A., Quirion R., Simonato M. Changes in NPY-mediated modulation of hippocampal [3H]D-aspartate outflow in the kindling model of epilepsy. Synapse 49, 116-124, 2003.
  65. Villetti G., Bergamaschi M., Bassani F., Bolzoni P.T., Maiorino M., Pietra C., Rondelli I., Chamiot-Clerc P., Simonato M., Barbieri M. Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist CHF3381 in experimental models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther. 306, 804-814, 2003.
  66. Barbieri M., Bregola G., Buzzi A., Marino S., Zucchini S., Stables J.P., Bergamaschi M., Pietra C., Villetti G., Simonato M. Mechanisms of action of CHF3381 in the forebrain. Br. J. Pharmacol. 139, 1333-1341, 2003.
  67. Binaschi A., Bregola G., Simonato M. On the role of somatostatin in seizure control: clues from the hippocampus. Rev. Neurosci. 14, 285-301, 2003.
  68. Gallerani M., Manzoli N., Fellin R., Simonato M., Orzincolo C.: Anaphylactic shock and acute pulmonary edema after a single oral dose of acetazolamide. Am. J. Emerg. Med. 20, 371-372, 2002.
  69. Bregola G., Zucchini S., Frigati L., Candeletti S., Romualdi P., Reinscheid R., Simonato M.: Involvement of the neuropeptide Orphanin FQ/Nociceptin in kainate and kindling seizures and epileptogenesis. Epilepsia 43 (S5), 18-19, 2002.
  70. Simonato M., Bregola G., Armellin M., Del Piccolo P., Rodi D., Zucchini S., Tongiorgi E.: Dendritic Targeting of mRNAs for Plasticity genes in experimental models of temporal lobe epilepsy. Epilepsia 43 (S5), 153-158, 2002.
  71. Zucchini S., Buzzi A., Bergamaschi M., Pietra C., Villetti G., Simonato M.: Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. NeuroReport 13, 2071-2074, 2002.
  72. Bregola G., Zucchini S., Rodi D., Binaschi A., D’Addario C., Landuzzi D., Reinscheid R., Candelotti S., Romualdi P., Simonato M.: Involvement of the neuropeptide Nociceptin/Orphanin FQ in kainate seizures. J. Neurosci. 22, 10030-10038, 2002.
  73. Marti M., Bregola G., Binaschi A., Gemignani A., Simonato M.: Kindled seizure-evoked somatostatin release in the hippocampus: inhibition by MK-801. NeuroReport 11, 3209-3212.
  74. Gallerani M., Manfredini R., Dal Monte D., Calò G., Brunaldi V., Simonato M.: Circadian differences in the individual sensitivity to opiate overdose. Crit. Care Med. 29, 96-101, 2001.
  75. Villetti G., Bregola G., Bassani F., Bergamaschi M., Rondelli I., Pietra C., Simonato M.: Preclinical evaluation of CHF3381 as a novel antiepileptic agent. Neuropharmacology 40, 866-878, 2001.
  76. Simonato M., Manservigi R., Marconi P., Glorioso J.: Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors. Trends Neurosci. 23, 183-190, 2000.
  77. Marti M., Bregola G., Morari M., Gemignani A., Simonato M.: Somatostatin release in the hippocampus in the kindling model of epilepsy: a microdialysis study. J. Neurochem. 74, 2497-2503, 2000.
  78. Bregola G., Dumont Y., Fournier A., Zucchini S., Quirion R., Simonato M.: Decreased levels of neuropeptide Y5 receptor binding sites in two experimental models of epilepsy. Neuroscience 98, 697-703, 2000.
  79. Bregola G., Frigati L., Zucchini S., Simonato M.: Different patterns of induction of FGF-2 and BDNF mRNAs during kindling epileptogenesis, and development of a herpes simplex vector for FGF-2 gene transfer in vivo. Epilepsia 41, S122-S126, 2000.
  80. Bregola G., Candeletti S., Romualdi P., Simonato M.: Limbic seizures increase pronociceptin mRNA levels in the thalamic reticular nucleus. NeuroReport 10, 541-546, 1999.
  81. Bregola G., Varani K., Gessi S., Beani L., Bianchi C., Borea P.A., Regoli D., Simonato M.: Changes in hippocampal and cortical B1 bradykinin receptor biological activity in two experimental models of epilepsy. Neuroscience 92, 1043-1049, 1999.
  82. Simonato M., Marconi P., Glorioso, J., Manservigi R.: Molecular analysis of behavior by gene transfer into neurons with herpes simplex vectors. Brain Res. 835, 37-45, 1999.
  83. Marconi P., Simonato M., Zucchini S., Bregola G., Argnani R., Krisky D., Glorioso J., Manservigi R.: Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo. Gene Therapy 6, 904-912, 1999.
  84. Romualdi P., Bregola G., Donatini A., Capobianco A., Simonato M.: Region-specific changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures. J. Mol. Neurosci. 13, 69-76, 1999.
  85. Simonato M., Bregola G., Beani L., Vezzani A., Sala R., Raiteri M., Bonanno G.: Time- and region-specific variations in somatostatin release following amygdala kindling in the rat. J. Neurochem. 70, 252-259, 1998.
  86. Simonato M., Molteni R., Bregola G., Muzzolini A., Piffanelli M., Beani L., Racagni G., Riva M.: Different patterns of induction of FGF-2, FGF-1 and BDNF mRNAs during kindling epielptogenesis in the rat. Eur. J. Neurosci. 10, 955-963, 1998.
  87. Lerea L.S., Carlson N.G., Simonato M., Morrow J.D., Roberts J.L., McNamara J.O.: Prostaglandin F2a is required for NMDA receptor-mediated induction of c-fos mRNA in dentate gyrus neurons. J. Neurosci. 17, 117-124, 1997.
  88. Simonato M.: Cortical and limbic dopamine (on opiate addiction): do not mix before use! Reply. Trends Pharmacol. Sci. 18, 77-78, 1997.
  89. Muzzolini A., Bregola G., Bianchi C., Beani L., Simonato M.: Characterization of glutamate and [3H]D-aspartate outflow from various in vitro preparations of the rat hippocampus. Neurochem. Int. 31, 113-124, 1997.
  90. Simonato M.: Temporal lobe epilepsy: the expression of regulatory genes in an experimental model. Leader Chem. 5, 10-15, 1994.
  91. Simonato M., Bregola G., Bianchi C., Beani L.: Effect of arachidonic acid on [3H]d-aspartate outflow in the rat hippocampus. Neurochem. Res. 19, 195-200, 1994.
  92. Simonato M., Varani K., Muzzolini A., Bianchi C., Beani L., Borea P.A.: Adenosine A1 receptors in the rat brain in the kindling model of epilepsy. Eur. J. Pharmacol. 265, 121-124, 1994.
  93. Hosford D.A., Simonato M., Cao Z., Garcia-Cairasco N., Silver J.M., Butler L., Shin C., McNamara J.O.: Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. J. Neurosci. 15, 2513-2523, 1995.
  94. Romualdi P., Donatini A., Bregola G., Bianchi C., Beani L., Ferri S., Simonato M.: Early changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat. Eur. J. Neurosci. 7, 1850-1856, 1995.
  95. Bianchi C., Ferraro L., Tanganelli S., Morari M., Spalluto G., Simonato M., Beani L.: 5-Hydroxytryptamine-mediated effects of nicotine on endogenous GABA efflux from guinea-pig cortical slices. Br. J. Pharmacol. 116, 2724-2728, 1995.
  96. Varani K., Beani L., Bianchi C., Borea P.A., Simonato M.: Changes in [3H]UK14304 binding to alpha-2 adrenoceptors in morphine-dependent guinea-pigs. Br. J. Pharmacol. 116, 3125-3132, 1995.
  97. Bregola G., Muzzolini A., Mazzari S., Leon A., Skaper S.D., Beani L., Bianchi C., Simonato M.: Biotin-deficiency facilitates kindling hyperexcitability in rats. Neuroreport 7, 1745-1748, 1996.
  98. Simonato M., Bregola G., Donatini A., Bianchi C., Beani L., Ferri S., Romualdi P.: Kindled seizure-induced c-fos and prodynorphin mRNA expressions are unrelated in the rat brain. Eur. J. Neurosci. 8, 2064-2067, 1996.
  99. Simonato M.: The neurochemistry of morphine addiction in the neocortex. Trends Pharmacol. Sci. 17, 410-415, 1996.
  100. Simonato M., Romualdi P.: Dynorphin and epilepsy. Prog. Neurobiol. 50, 557-583, 1996.
  101. Beani L., Tanganelli S., Antonelli T., Simonato M., Spalluto P., Tomasini C., Bianchi C.: Changes in cortical ACh and GABA outflow during morphine withdrawal involve alpha-1 and alpha-2 receptors. J. Pharmacol. Exp. Ther. 250, 682-687, 1989.
  102. Tanganelli S., Antonelli T., Simonato M., Spalluto P., Tomasini C., Bianchi C., Beani L.: Alpha-1 adrenoreceptor-mediated increase in ACh release in brain slices during morphine tolerance. J. Neurochem. 53, 1072-1076, 1989.
  103. Simonato M., Snead O.C., Jope R.S.: Electroencephalographic effects of intracerebro-ventricularly administered opioids: effects of lithium. Res. Commun. Psychol. Psichiatry Behav. 14, 207-243, 1989.
  104. Beani L., Bianchi C., Ferraro L., Morari M., Simonato M., Spalluto G., Tanganelli S.: Alpha-2-adrenoreceptor-mediated decrease in gamma-amino-butyric outflow in cortical slices and synaptosomes during morphine tolerance. J. Pharmacol. Exp. Ther. 258, 472‑ 476, 1991.
  105. Simonato M., Hosford D.A., Labiner D.M., Shin C., Mansbach H.H., McNamara J.O.: Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy. Mol. Br. Res. 11, 115-124, 1991.
  106. Simonato M.: A pathogenetic hypothesis of temporal lobe epilepsy. Pharmacol. Res. 27, 217-225, 1993.
  107. Simonato M., Bregola G., Muzzolini A., Bianchi C., Beani L.: Characterization of K+-evoked [3H]d-aspartate outflow in the rat hippocampus in vitro. Neurochem. Int. 23, 555-560, 1993.
  108. Ferraro L., Tanganelli S., Calo’ G., Antonelli T., Fabrizi A., Acciarri N., Bianchi C., Beani L., Simonato M.: Noradrenerigic modulation of gamma-aminobutyric acid outflow from the human cerebral cortex. Brain Res. 629, 103-108, 1993.
  109. Simonato M., Jope R.S., Bianchi C., Beani L.: Lack of excitatory amino acids-induced effects on calcium fluxes measured with 45Ca2+ in rat cerebral cortex synaptosomes. Neurochem. Res. 14, 677-682, 1989.
  110. Johnson G.V.W., Simonato M., Jope R.S.: Dose- and time-dependent hippocampal cholinergic lesions induced by ethylcholine mustard aziridinium ion: effects of nerve growth factor, GM1 ganglioside and vitamin E. Neurochem. Res. 13, 685-692, 1988.
  111. Beani L., Bianchi C., Tanganelli S., Antonelli T., Simonato M., Rando S.: Inversion of the alpha-2 and alpha-1 noradrenergic control of the cortical release of acetylcholine and gamma-aminobutyric acid in morphine-tolerant guinea-pigs. J. Pharmacol. Exp. Ther. 247, 294-301, 1988.
  112. Jope R.S., Simonato M., Lally K.: Acetylcholine content in rat brain is elevated by status epilepticus induced by lithium and pilocarpine. J. Neurochem. 49, 944-951, 1987.
  113. Antonelli T., Beani L., Bianchi C., Rando S., Simonato M., Tanganelli S.: Cortical acetylcholine release is increased and GABA outflow is reduced during morphine withdrawal. Br. J. Pharmacol. 89, 853-860, 1986.